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Description

GP100072: MUC1(126-149)-Tn(139,144)C111H175N31O42 2615. 76 MUC1 synthetic glycopeptide. Glycosylated Mucin 1 (MUC1) peptide fragment containing amino acid sequence Pro126Gly149 (24 AA in length) from the tandem repeat (TR) region of the MUC1 protein. The fragment contains tumor associated carbohydrate antigen (TACA), Tn antigen, O glycosylation ( GalNAc) at Thr139 and Thr144. The C terminus is carboxylic acid. MUC1(126 149) Tn(139,144) Mucin1; Synthetic MUC 1 (di Tn) glycopeptide

biosynthesis substrate

/ β-D-Lac-Ethyl-Thiol / β-Lac-Et-SH

Ser140 and Thr144

C83H146N14O34S / 1916

The installed glycan is a melibiose (Galα1-6Glc) disaccharide

TRMUC4-Ser5-Tn

71 / An Fmoc-protected L-tyrosine building block carrying a β-D-glucose residue on the phenolic oxygen

and is bound by Anti-Tn Antigen [237mAb]

Fmoc-Ser(β-L-Rhamnose)-OH (Peracetate)

6-glucosidase

5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonate)-(2→3)-2

Synthetic MUC-1 (tri-Tn) glycopeptide