AG124010: β-D-GalNAc-Ethyl-Azide (Peracetate)

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Description

AG124010: β-D-GalNAc-Ethyl-Azide (Peracetate)C16H24N4O9 416. 38 A peracetylated D N acetylgalactosamine (GalNAc) ligand equipped with an azide functionalized linker through a short ethyl spacer, with the sugar hydroxyl groups protected as acetate esters. The peracetate groups increase lipophilicity to facilitate cell membrane permeability. The terminal azide can be covalently coupled to alkyne partners via copper catalyzed azide alkyne cycloaddition (CuAAC), or to dibenzocyclooctyne (DBCO) and

This compound enables the construction of hepatocyte-targeted therapeutics and research tools that exploit the asialoglycoprotein receptor (ASGPR)

β-D-Glc-Et-N3

β-D-Lac-Et-NH2

C33H53N5O18S / 839

β-D-Gal-Et-N3

2-Aminoethyl β-D-glucopyranoside

β-D-(Galβ1-4Glc)-O-(CH2)2-NH2

Neu5Acα2-6Galβ1-4GlcNAcβ-O(CH2)3-NH2

32 / An α-D-N-acetylgalactosamine (GalNAcα) ligand equipped with a terminal carboxylic acid through a short butyl spacer

32 / A β-D-N-acetylglucosamine (GlcNAcβ) ligand equipped with a terminal carboxylic acid through a short butyl spacer

/ β-GlcNAc-Ethyl-Amine / β-D-GlcNAc-O-(CH2)2-NH2

GalNAcα1-O-Thr) equipped with a biotin tag through an amide bond