GP100110: Arg8-CGSG-MUC1(137-156)-Tn(144)

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Description

GP100110: Arg8-CGSG-MUC1(137-156)-Tn(144)C146H253N63O45S 3643. 03 MUC1 (UniProt ID P15941) synthetic glycopeptide fragment (Gly137 His156; UniProt position 137 156, aa length 20) from the variable number tandem repeat (TR) domain. The fragment contains tumour associated carbohydrate antigen (TACA), Tn (GalNAc O Thr) at Thr144. Arg8 is conjugated at N terminal. Arg8 is separated from the MUC1 sequence by Cys Gly Ser Gly. The C terminus is an amide. Arg8 CGSG MUC1(137 156) Tn(144) Mucin1; R8

9 / An Fmoc-protected L-serine building block carrying a GlcNAcβ1-3GalNAcα disaccharide

β-D-(Galβ1-4GlcNAc)-O-(CH2)2-N3

C29H44D6O2 / 436

or to dibenzocyclooctyne (DBCO) and related strained alkynes using copper-free click chemistry

(+)-Vitamin D2-d3

Neu5Acα(2-6)GalNAc-α-1-O-Serine

236) / Immunoglobulin heavy constant alpha 1 (IGHA1)

6-tri-O-acetyl-2-acetamido-2-deoxy-β-D-galactopyranoside

33 / A β-D-galactose ligand equipped with a primary amine through a hydrophilic PEG3 spacer

C17H32N2O11 / 440

Terminal α-Gal residues are also a substrate for glycosyltransferases and relevant to studies of the α-Gal epitope (Galα1-3Gal) and anti-Gal antibody recognition

This compound provides a lactose (Galβ1-4Glc) building block for glycoconjugate synthesis and the construction of probes for galactose-recognizing proteins

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