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Description

AG124005: β-D-GalNAc-Ethyl-AzideC10H18N4O6 290. 27 A D N acetylgalactosamine (GalNAc) ligand equipped with an azide functionalized linker through a short ethyl spacer. The terminal azide can be covalently coupled to alkyne partners via copper catalyzed azide alkyne cycloaddition (CuAAC), or to dibenzocyclooctyne (DBCO) and related strained alkynes using copper free click chemistry, forming stable 1,2,3 triazole linkages. This compound enables the construction of hepatocyte targeted

in which the sugar hydroxyls are protected as acetate esters

22 / An α-D-galactose ligand equipped with an amine-functionalized linker through a short ethyl spacer

This probe can be used as a soluble inhibitor or immobilized on plates or sensors to investigate binding

65 / / 1-α

/ α-D-Gal-Ethyl-Amine / α-Gal-Et-NH2

/ β-D-Glc-Ethyl-Thioacetate / β-Glc-Et-SAc

a non-reducing-end fragment relevant to the glycosaminoglycan-protein linkage region (the GAG tetrasaccharide linker GlcAβ1-3Galβ1-3Galβ1-4Xyl-O-Ser includes a xylose-glucuronic acid junction)

α-L-Rha-Et-NH2

β-D-(Galβ1-4Glc)-O-(CH2)2-COOH

/ β-D-GalNAc-Hexyl-Amine / β-D-GalNAc-Hex-NH2

32 / A β-D-N-acetylglucosamine (GlcNAcβ) ligand equipped with a terminal carboxylic acid through a short butyl spacer

4 / An α-D-N-acetyllactosamine (LacNAc) ligand equipped with an amine-functionalized linker through a short propyl spacer

Exchange/Return Notes